App Note: High-Throughput Raman Analysis of Protein Glycosylation


The market for monoclonal antibody (MAb) therapeutics is projected to reach a value of USD $350 billion by the end of 2027. The production and purification of MAbs can be challenging. These molecules are prone to several types of post-translational modifications that may reduce their efficacy and limit shelf life. The most prevalent modifications include glycosylation, misfolding, aggregation, oxidation, deamidation, and proteolysis. Over one-third of MAb and recombinant protein therapeutic agents are glycoproteins3 and glycosylation is one of the most common post-translational modifications in these biopharmaceuticals.

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