Throughout the year, we host informative Raman spectroscopy webinars where you can learn more about our Raman spectroscopy solutions and what they can do for you. If you missed any of our live presentations, you can catch-up by viewing the recordings located below. For more information, please feel free to contact us at 416-361-3444 or email [email protected].
Webinars
High-Throughput Raman to Monitor Tablet Coating
In this webinar we examine the value of using Tornado Spectral Systems’ high-throughput Raman spectroscopic instrumentation for monitoring tablet coating processes. The data will demonstrate that Tornado probes can be adapted to meet the demands of different sampling situations and that the HTVS-enabled spectroscopic performance allows quality data to be collected allowing actionable information. While the coatings used in this case for demonstration were cosmetic, the technology can easily be applied to functional coatings as well as coatings with APIs. While there is value in employing a Raman monitoring strategy with cosmetic coatings, there is increased benefit in the case of functional and API-containing coatings because of the critical role they play in the therapeutic performance of such products.
Request the webinar and learn how Tornado Raman can be a valuable tool in monitoring coating procedures to confirm the process is proceeding properly, to elucidate endpoints, and to track excursions, should they occur, on a molecular basis.
High-Throughput Raman for Various Aspects of Downstream Processing:
Monitoring Protein Capture, Assessing CQAs, and Other Value-Added Measurements
In this webinar, we explore the use of HTVS™ powered Raman spectroscopy as a monitoring tool and assess the results, in terms of the speed, specificity of quantification of protein elution profiles (and how this can provide optimized column switching times in continuous capture processes), protein glycosylation information, and chemical information regarding protein denaturation.
Learn more on how obtaining this highly detailed chemical information faster, with better signal-to-noise ratios, and lower limits of detection, can lead to large improvements in downstream protein monitoring efficiency, yield, and purity.
Industry 4.0 and the Process Guardian
Industry 4.0 is the advancement of manufacturing that uses Internet-of-Things technology and Industry 4.0 applications to ensure total process monitoring and quality assurance.
This presentation sheds light on the history of Industry 4.0 movement, and spotlights how the Tornado Process Guardian Raman spectrometer (PGR) fits within the Industry 4.0 paradigm. Key concepts of Automation, Quality Predictive Control, and Vertical and Horizontal Integration are also explored in this presentation.
Understanding your photons – Optimizing the quality of process Raman measurements
If you are a process chemist, process engineer, or production manager, you probably do not think a lot about photons. You concentrate on running a smooth process, avoiding problems, increasing yield, and other such important factors. But if you are using Raman spectroscopy for process monitoring, photons are the fundamental source of your chemical information, and it’s critical to understand their properties to have confidence in your real-time process measurements.
This presentation provides an accessible high-level overview of photon statistics, signal-to-noise ratio, and chemometric measurement precision for chemists, engineers, and managers in the petrochemical, pharmaceutical, specialty chemical, polymer and other industries who use Raman measurements or who are considering adopting Raman spectroscopy as a process analytic technology.
Inherently Safe Raman Measurements for Hazardous Zones
In the following webinar, we will provide process Raman users with a basic understanding of the regulatory requirements, explain how the OPIS 35 accessory achieves compliance, and share some examples illustrating the data quality and measurement precision that can be achieved with Tornado’s ATEX-compliant solution.
This webinar is designed for process development chemists, process control engineers and operations managers in the petrochemical, pharmaceutical, specialty chemical, polymer and other industries who need to comply with safety requirements in an ATEX zone without sacrificing quantitative measurement performance.
Exploring the Limits of Detection of a Model Compound in a Flow Scenario using High-Throughput Raman Spectroscopy
The concept of the limit of detection (LOD) has been, and still is, one of the most debated in analytical chemistry. Determination of a limit of detection seems to be a simple process, but it is one of the most misunderstood concepts with regards to chemical analysis and measurement. When low detection limits are needed to measure analytes below specified limits, those monitoring the process must be able to demonstrate its capability to meet those requirements.
This presentation provides a flow chemistry example illustrating the potential for high sensitivity with Raman measurements. Viewers will be presented with an accessible high-level overview of how Tornado’s HTVS™ technology allows higher-throughput measurements which lead to better time resolution, sensitivity, and quantitative resolution/accuracy.
Process Analytics for 21st Century Manufacturing
The 21st century is witness to fundamental changes in manufacturing as it remains a critical force in both advanced and developing economies. There has been a paradigm shift that is brewing within the pharmaceutical industry and related fields, including process analytics in advanced manufacturing. Today’s manufacturer faces an era where the problem is no longer one of not being able to collect enough data on manufacturing processes but when to incorporate process analytics and understand the challenges for successful implementation.
Key Learning Objectives
- Understand when we need process analytics in advanced manufacturing
- Understand some of the challenges in implementing process analytics successfully
- Understand the particular benefits in using Raman spectroscopy
High Throughput Virtual Slit™ (HTVS™) Impact On Raman Spectroscopy Limit Of Detection (LoD) Performance
In this webinar, we present an LoD study and discuss the improved detection limits and corresponding minimum required acquisition times of 4 binary mixtures using Tornado’s HyperFlux™ PRO Plus Raman spectrometer.
You will learn how the HyperFlux™ PRO Plus demonstrates:
- Better sensitivity for lower detection limits
- Faster measurements
- Why it is more feasible to deploy for real-time applications
Why Raman for Process?
Raman spectroscopy has been used as a process analysis tool for 30 years or more. However, it has only been in the past three to five years that interest in Raman as a PAT tool has increased dramatically. That has, in part, been due to the increase in the activity for bioprocessing, which is an area for which Raman is a technique of high interest. But apart from the bio area, there has been a general awakening to the benefits of specificity, interpretability and process understanding that are realized by using Raman for Process Development, Process Monitoring and Process Control. The increases in the sensitivity of Raman measurements brought about by the High Throughput Virtual Slit (HTVS™) technology has also added to the attractiveness of the Raman technique.
The theme that will be explored with this presentation will be why Raman should be considered when choosing a process tool. What does Raman bring to the table when considering all of the options out there that can make the measurements that need to be made? The practical advantages of Raman will be surveyed from the standpoint of specificity, interpretability, sensitivity, sampling and quantifiability.
High-Throughput Raman Process Monitoring of Downstream Protein Purification
Eliminate the protein purification analysis bottleneck: Tornado’s High-Throughput Virtual Slit (HTVS™) brings high-throughput data management and analysis to downstream protein purification.
Managing downstream data from a pharmaceutical protein purification process is a complex challenge even if you run just a few experiments per month. With Tornado’s Raman analyzer, this can quickly scale up to hundreds of automated, parallelised experiments.
Discover how the HyperFlux™ PRO Plus allows higher throughput measurements and can predict the chromatographic elution concentrations of individual proteins with a high degree of specificity. Used effectively as part of a downstream protein purification process strategy, the data generated from Raman analysis can accelerate development by supporting better decision making, enhance process understanding and control of the manufacturing process, and increase yields and profitability.
