Tornado’s Raman spectrometers with revolutionary technology exhibit an exceptional signal-to-noise ratio (SNR) compared to conventional Raman spectrometers, driven by the patented High Throughput Virtual Slit (HTVS^TM) technology. This facilitates in-line, real-time process measurements of analytes with exceptionally low concentrations. As a demonstration of this, we show the measurement of sodium perchlorate with a Limit of Detection (LoD) of less than 3 parts per million (ppm), the lowest detection limit yet seen on this device as of the time of this writing. The ability of the Tornado Raman spectrometer to accurately and reproducibly measure perchlorate allows it to be used with confidence to detect and quantify perchlorate as a contaminant at low levels.