Chemical: Real-time Reaction Monitoring

The HyperFlux™ PRO Plus Raman spectrometer for real-time process monitoring of chemical reaction kinetics enables reaction condition optimization, analysis of kinetics, and identification of optimal reaction endpoints.

Tornado’s HyperFlux™ PRO Plus provided a fast and accurate monitoring tool to confirm reaction quality and optimize reaction timing. HyperFlux™ PRO Plus allows fast data collection for greater data density which enhances tracking process changes, determining reaction kinetics, optimizing reaction conditions, flagging process upsets, and turning batches over more quickly compared to other Raman spectrometers.

Measurement of Low Analyte Concentrations Using HTVS-enabled Raman Spectrometer

Tornado’s Raman spectrometers with revolutionary technology exhibit an exceptional signal-to-noise ratio (SNR) compared to conventional Raman spectrometers, driven by the patented High Throughput Virtual Slit (HTVSTM) technology. This facilitates in-line, real-time process measurements of analytes with exceptionally low concentrations. As a demonstration of this, we show the measurement of sodium perchlorate with a Limit of Detection (LoD) of less than 3 parts per million (ppm), the lowest detection limit yet seen on this device as of the time of this writing. The ability of the Tornado Raman spectrometer to accurately and reproducibly measure perchlorate allows it to be used with confidence to detect and quantify perchlorate as a contaminant at low levels.

Monitoring of Cannabis Extraction in Supercritical CO2

In this white paper, we describe how Tornado’s Raman Spectrometer can be used for real-time quantification of CBD in SC-CO2 as it is being extracted from cannabis flowers during a semicontinuous process. As cannabis is composed of hundreds of different compounds, the ability of Tornado’s Raman spectrometer to produce chemical fingerprints is uniquely suited for cannabis extraction monitoring. Critical materials can be speciated and quantified in real-time. With the 10x signal advantage of HTVS™, Tornado can offer Raman process analyzer systems with best-in-market sensitivity and specificity.

Monitoring of Phyto-cannabinoid Extraction

Cannabis sativa is a unique and valuable plant, particularly due to its ability to produce Phyto-cannabinoids. The best known of this group of compounds are cannabidiol (CBD) and ∆9-tetrahydrocannabinol (∆9-THC). The commercial significance of Phyto-cannabinoids has
increased dramatically in recent years due to the evolution of the legal status of these materials.

The work shown in this note will demonstrate that Tornado Raman spectrometers can add value to the extraction steps used in phytocannabinoid processing. The data presented in this report show that Raman analysis using the Tornado’s HyperFlux™ PRO Plus Raman Analyzer can be used to quantitatively analyze CBD at low concentrations (1000 to 5500 ppm).

Nitrogen Content and Agrochemicals

One of the most prolific uses of Raman has been to analyze nitrogen content specific to products containing chemicals such as urea or nitrates. By utilizing Raman technology, both researchers and commercial entities have been able to quantify nitrogen in materials critical to agricultural needs. With a wide range of uses and our patented HTVS technology, our Tornado’s Raman spectrometers can add understanding and be used for process control and monitoring for a wide range of agricultural chemical processes.

Gas Measurements

The use of Raman Spectroscopy in oil refineries and other petroleum processes has largely increased in the last few years. Monitoring of gases either in the reactor headspace or in the process lines is vitally important to ensuring process understanding. With Raman spectrometers from Tornado Spectral Systems, gases such as Carbon Dioxide (CO2), Carbon Monoxide (CO), Methane (CH4) and other hydrocarbons can be measured. Homonuclear diatomics not able to be measured by IR such as Hydrogen (H2), Nitrogen (N2), Oxygen (O2) can also be quantified. H2 is of particular interest since it is a difficult analyte by other common process analytical techniques.

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Case Studies

Learn more about our applications by reviewing our case studies pages.

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“The Tornado HyperFlux PROPlus has gathered thousands of reproducible spectra since we acquired it in mid-2019 without requiring a single repair.”

What our
clients say

– Angela Spangenberg, Senior Research Scientist, DisperSol Technologies