Chemical: Real-time Reaction Monitoring

The HyperFlux™ PRO Plus Raman spectroscopy system for real-time process monitoring of chemical reaction kinetics enables reaction condition optimization, analysis of chemical conversion rates, and identification of optimal reaction endpoints.

Tornado’s HyperFlux™ PRO Plus provided a fast and accurate monitoring tool to confirm reaction quality and optimize reaction timing. HyperFlux™ PRO Plus allows fast data collection for greater data density which enhances tracking process changes, determining reaction kinetics, optimizing reaction conditions, flagging process upsets, and turning batches over more quickly compared to other Raman instruments.

Measurement of Sodium Perchlorate Using HTVS-enabled Raman Spectroscopy

Tornado’s Raman analyzers with revolutionary spectrometer technology exhibit an exceptional signal-to-noise ratio (SNR) compared to conventional Raman spectrometers, driven by the patented High Throughput Virtual Slit (HTVSTM) technology. This facilitates in-line, real-time process measurements of analytes with exceptionally low concentrations. As a demonstration of this, we show the measurement of sodium perchlorate with a Limit of Detection (LoD) of less than 3 parts per million (ppm), the lowest detection limit yet seen on this device as of the time of this writing. The ability of the Tornado Raman spectrometer to accurately and reproducibly measure perchlorate allows it to be used with confidence to detect and quantify perchlorate as a contaminant at low levels.

Monitoring of Cannabis Extraction in Supercritical CO2

In this white paper, we describe how Tornado’s Raman Spectrometer can be used for real-time quantification of CBD in SC-CO2 as it is being extracted from cannabis flowers during a semicontinuous process. As cannabis is composed of hundreds of different compounds, the ability of Tornado’s Raman spectroscopy to produce chemical fingerprints is uniquely suited for cannabis extraction monitoring. Critical materials can be speciated and quantified in real-time. With the 10x signal advantage of HTVS™, Tornado can offer Raman process analyzer systems with best-in-market sensitivity and specificity.

Monitoring of Phyto-cannabinoid Extraction

Cannabis sativa is a unique and valuable plant, particularly due to its ability to produce Phyto-cannabinoids. The best known of this group of compounds are cannabidiol (CBD) and ∆9-tetrahydrocannabinol (∆9-THC). The commercial significance of Phyto-cannabinoids has
increased dramatically in recent years due to the evolution of the legal status of these materials.

The work shown in this note will demonstrate that Tornado Raman Analyzers can add value to the extraction steps used in phytocannabinoid processing. The data presented in this report show that Raman analysis using the Tornado’s HyperFlux™ PRO Plus Raman Analyzer can be used to quantitatively analyze CBD at low concentrations (1000 to 5500 ppm).

Nitrogen

In recent years, the use of Raman Spectroscopy for quality control and monitoring of agricultural chemical products has gained more acceptance and wider usage. Raman has been shown to be useful in quantifying the nitrogen content of fertilizer materials, which relates directly to their effectiveness, to their fitness for purpose and to their overall quality. One of the most prolific uses of Raman has been to analyze nitrogen content specific to products containing chemicals such as urea or nitrates. By utilizing Raman technology, both researchers and commercial entities have been able to quantify nitrogen in materials critical to agricultural needs. With a wide range of uses and our patented HTVS technology, our Tornado’s Raman analyzers can add understanding and be used for process control and monitoring for a wide range of agricultural chemical processes.

Gas Measurements

The use of Raman Spectroscopy in oil refineries and other petroleum processes has largely increased in the last few years. Monitoring of gases either in the reactor headspace or in the process lines is vitally important to ensuring process understanding. With Raman analyzers from Tornado Spectral Systems, gases such as Hydrogen (H2), Nitrogen (N2), Oxygen (O2), Carbon Dioxide (CO2), and Methane (CH4) can be quantified across a wide range of temperatures, pressures, and concentrations. Tornado’s Raman spectroscopy allows for simultaneous inline, non-destructive analysis of these gases that provide actionable information in real-time.

Polycarbonate resins

The polycarbonate production industry produces more than 2.5 million tons of material annually. Polycarbonate resins are known for their transparency, impact resistance, and thermal resistance. Tornado’s Raman Spectrometer based Analyzers can be used for analyzing and quantify starting material such as diphenyl carbonate and phenol, measuring reaction processes, and even examining the final structure of the product. Some of the defining characteristics of the final product directly relate to the ordered structure. Raman spectroscopy has the ability to analyze the ordered structures of polycarbonate in process to allow detailed analysis of product suitability. Raman can also be used to monitor the reactions that produce the polycarbonate, and to quantify the starting materials, the product, the residual monomer and the side products in the process in real time. This in-line monitoring can help assure product quality and integrity and help to maintain production efficiency, thereby reducing waste and downtime. See how HTVS-enabled process Raman spectroscopy from Tornado Spectral Systems can optimize your polycarbonate process.

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Case Studies

Learn more about our applications by reviewing our case studies pages.

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“The Tornado HyperFlux PROPlus has gathered thousands of reproducible spectra since we acquired it in mid-2019 without requiring a single repair.”

What our
clients say

– Angela Spangenberg, Senior Research Scientist, DisperSol Technologies